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G- 细菌的脂多糖 (L PS)是重要的病原体相关模式分子。PAMPs均可被动物作为外来分子进行识别。L PS能激发机体细胞因子 IL- 1、TNF- α等活性分子的合成 ,对感染具有十分重要的作用。L PS是通过什么受体怎样将信号传入免疫细胞并启动免疫反应的 ,人们一直都不十分清楚。近年来 ,一种名为 Toll蛋白的发现 ,使人们对机体识别 L PS机制的认识向前跨进了一大步。本文试对该模式识别受体的研究进展做一综述
G-bacterial lipopolysaccharide (LPS) is an important pathogen-associated pattern molecule. PAMPs can be recognized as foreign molecules by animals. L PS can stimulate the synthesis of cytokines such as IL-1 and TNF-α and play an important role in the infection. It is not always clear how LPS acts by which receptors transmit signals to immune cells and initiate an immune response. In recent years, a discovery called Toll protein has led to a big step forward in understanding the mechanism of LPS recognition. This article attempts to review the progress of this pattern recognition receptor