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发展了一种有机催化靛红与4-苯基-3-丁炔-2-酮的反应,提供了高效合成3-取代-3-羟基氧化吲哚类衍生物的方法.该方法所采用的有机催化剂廉价易得,靛红底物中氮原子无需保护,反应操作简单,条件温和,各种不同取代基的靛红以及4-芳基-3-丁炔-2-酮都能较好地参与反应且以较高的收率合成目标产物.另外,该体系也可用于催化靛红与3-己炔-2-酮的反应.
An organic catalytic reaction of isatin with 4-phenyl-3-butyn-2-one was developed to provide a highly efficient method for the synthesis of 3-substituted-3-hydroxyindole derivatives. The organic catalyst is cheap and easily available, the nitrogen atom in the isatin red need not be protected, the reaction is simple and the conditions are mild, and the isostenes with various substituents and the 4-aryl-3-butyn-2-ones are better Participate in the reaction and synthesize the target product with higher yield.In addition, the system can also be used to catalyze the reaction of isatin with 3-hexyn-2-one.