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目的探讨肌萎缩侧索硬化症 (ALS)的临床诊断依据及发病机理。方法根据ALS的诊断标准对 95例ALS进行重新诊断 ,结合文献及本组病例对ALS的病因及发病机理进行讨论。结果 本组肯定为ALS 5 9例 (62 .11% ) ,拟诊ASL3 2例 (3 3 .68% ) ,可能为ASL 4例 (4.2 1% )。结论临床症状、体征以及肌电图是ASL的临床诊断及鉴别诊断依据 ,其病因及发病机理未完全明了
Objective To investigate the clinical diagnosis basis and pathogenesis of amyotrophic lateral sclerosis (ALS). Methods Based on the diagnostic criteria of ALS, 95 patients with ALS were re-diagnosed. The etiology and pathogenesis of ALS were discussed in combination with the literature and this group of patients. Results In this study, 59 patients (62.11%) had ALS, 2 patients (33.68%) had ASL, and 4 patients (4.2%) had ASL. Conclusions Clinical symptoms, signs and electromyography are the basis of clinical diagnosis and differential diagnosis of ASL. The etiology and pathogenesis of ASL are not completely understood