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目的:观察头孢硫脒治疗小儿革兰阳性(G~+)球菌败血症的临床疗效。方法:75例小儿革兰阳性球菌败血症患儿随机分为A、B两组。A组予头孢硫脒50 mg·kg~(-1),ivd,q12 h;B组给予万古霉素10 mg·kg~(-1),静脉泵入,q8h。比较两组患儿疗效及不良反应。结果:两组有效率、痊愈率及住院时间比较,差异无统计学意义(P>0.05)。A组不良反应发生例数明显低于B组。结论:头孢硫脒治疗小儿G~+球菌败血症安全有效、不良反应少。
Objective: To observe the clinical efficacy of cefathiamidine in the treatment of Gram-positive (G ~ +) septicemia in children. Methods: Seventy-five children with Gram-positive septicemia were randomly divided into A and B groups. Group A received cefathiamidine 50 mg · kg -1, ivd, q12 h; group B received vancomycin 10 mg · kg -1, iv, q 8h. Efficacy and adverse reactions in both groups were compared. Results: There was no significant difference between the two groups in the effective rate, the cure rate and the length of hospital stay (P> 0.05). The incidence of adverse reactions in group A was significantly lower than that in group B. Conclusion: Cefathiamidine is safe and effective in the treatment of children with G ~ + cocci sepsis with few adverse reactions.