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目的探讨在儿童术前用药中采用鼻内滴注右美托咪定与口服咪唑安定的临床效果。方法 100例美国标准协会(American Standards Association,ASA)Ⅰ~Ⅱ级行择期简单手术的患儿随机均分为2组:M组(n=50)患儿将咪唑安定按照0.5 mg/kg加入5%葡萄糖注射液中进行口服,同时鼻内滴注安慰剂(生理盐水);D组(n=50)患儿则鼻内滴注右美托咪定1μg/kg,同时口服5%葡萄糖注射液。麻醉诱导前观察患儿镇静状态、行为评分,监测血压、心率以及氧饱和度,同时记录苏醒状态。结果在与父母分离时行为及诱导行为表现方面两组患者无显著性差异。和M组患者相比,D组患儿在与父母分离时以及麻醉诱导期间镇静更为显著(P<0.05)。结论与口服咪唑安定相比,两种给药途径患儿依从性相似,但鼻内滴注右美托咪定可以提供更理想的镇静状态。
Objective To investigate the clinical efficacy of intranasal drip dexmedetomidine and oral midazolam in preoperative medication in children. Methods One hundred patients with stage Ⅰ ~ Ⅱ simple American Society of Standards Association (ASA) were randomly divided into two groups: M group (n = 50) received midazolam 0.5 mg / kg (N = 50) were given intranasal dexmedetomidine 1μg / kg intranasally, while oral 5% glucose injection . Before induction of anesthesia, the sedation, behavioral score, blood pressure, heart rate and oxygen saturation were observed and the state of wakefulness was recorded. Results There was no significant difference between the two groups in behavior and behavior-inducing behavior when separated from their parents. Compared with M group, children in group D sedated more significantly when separated from their parents and during induction of anesthesia (P <0.05). Conclusions Children with both routes of administration have similar compliance compared with oral midazolam, but intranasal drip of dexmedetomidine provides a more ideal sedative.