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阿苯达唑(ABZ)是一种广泛使用的治疗肠道和组织内蠕虫感染的苯并咪唑类药物,在肝脏微粒体中氧化形成阿苯达唑亚砜(ABZSO)和阿苯达唑砜(ABZSO_2)。Ri-cobendazole(RBZ)是一种由ABESO构成的苯并咪唑类抗蠕虫药。作者应用旋毛线虫小鼠模型观察并比较了ABZ与RBZ的驱虫活性及药代动力学图。
Albendazole (ABZ) is a widely used benzimidazole drug for the treatment of helminth infections in the gut and tissues. It is oxidized in the liver microsomes to form albendazole sulfoxides (ABZSO) and albendazole (ABZSO_2). Ri-cobendazole (RBZ) is a benzimidazole anthelmintic drug consisting of ABESO. The authors used Trichinella spiralis mouse model observed and compared ABZ and RBZ deworming activity and pharmacokinetic maps.