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目的 探讨娄底市大肠癌高危因素。方法 对 1990年 1月至 2 0 0 0年 12月住院治疗的 132例大肠癌患者 ,以院内非消化病患者为对照组进行 1∶1配对的病例对照研究。结果 统计方法采用条件logistic回归 ,单因素条件Logistic回归分析发现家族性肿瘤史、溃疡性结肠炎病史、肠息肉病史、血吸虫病史、激素替代治疗、社会经济状况、纤维素 (水果、蔬菜 )、脂肪、高温烧烤肉类、腌鱼和腌肉、吃油炸食品、钙摄入量、抽烟≥ 35年、体育活动与大肠癌发生有关联。条件Logistic多元回归模型筛选出 5个危险因素 ,即家族性肿瘤史、吃油炸食品、腌鱼和腌肉、抽烟≥ 35年、钙摄入量。结论 娄底市大肠癌的发生与家族性肿瘤史、吃油炸食品、腌鱼和腌肉、抽烟≥ 35年、钙摄入量密切相关。
Objective To investigate the risk factors of colorectal cancer in Loudi. Methods A case-control study was conducted on 132 patients with colorectal cancer hospitalized from January 1990 to December 2000 with 1: 1 matched non-digestive disease patients as the control group. Results Statistical methods were analyzed by conditional logistic regression and single factor conditional logistic regression analysis. The results of familial tumor history, history of ulcerative colitis, history of intestinal polyposis, history of schistosomiasis, hormone replacement therapy, socioeconomic status, cellulose (fruits and vegetables), fat , High-temperature barbecue meat, pickled fish and bacon, eat fried foods, calcium intake, smoking ≥ 35 years, physical activity associated with colorectal cancer. The conditional Logistic multiple regression model screened five risk factors, namely, familial tumor history, eating fried foods, salted fish and cured meat, smoking for 35 years, and calcium intake. Conclusions The occurrence of colorectal cancer in Loudi is closely related to the history of familial tumors, eating fried foods, salted fish and cured meat, smoking for 35 years and calcium intake.