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作者最近检查124名病史在半年以上的Ⅰ型青年糖尿病人,以Goldman方法测定了血清中抗胰岛素结合量,发现病人体内存在抗胰岛素抗体。为了比较,按HLA DR型的抗原型别将病人分为6组:3/3,3/一,4/4,4/一,3/4和一/一(一为非OR_3或OR_4)。病人平均年龄14.7±0.5岁,病程5.8±0.4年,病情控制以HbA1c均值在7.6±0.2％为标准.结果显示HLA DR型各组的年龄、病程、HbA1c水平,胰岛素的型号等无差异,显示DR 3/3组病人的抗胰岛素结合水平显著低于其他组(2.5±0.4vS,13.6±1.4μS/ml,(P<0.0001),DR 3/一组病人与其他组病人相比较,其抗胰岛素结合量无区别。
The authors recently examined 124 patients with type 1 diabetes mellitus who had a history of more than six months and measured the amount of anti-insulin binding in the serum using the Goldman method and found that the patient had anti-insulin antibodies. For comparison, patients were divided into 6 groups according to the antigenic type of HLA DR: 3/3, 3/4, 3/4, 3/4, and 1/1 (non-OR_3 or OR_4). The average age of patients was 14.7 ± 0.5 years and the duration of disease was 5.8 ± 0.4 years.The disease control was based on the standard of HbA1c at 7.6 ± 0.2% .The results showed that there was no difference in the age, course of disease, HbA1c level, insulin type, The level of anti-insulin binding was significantly lower in DR 3/3 patients than in other groups (2.5 ± 0.4 vs 13.6 ± 1.4 μS / ml, P <0.0001) Insulin binding no difference.