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硝苯吡啶(以下称NP)是钙拮抗药.主要用于治疗冠心病心绞痛及高血压病.近年来其临床应用日趋增多.现就NP在儿科的几种新用途介绍如下。1 小儿神经性尿频症张希润等用NP治疗小儿神经性尿频40例,结果1疗程治愈28例(70％).2个疗程全部治愈.疗法:0.5～1.0 mg·kg~(-1)·d~(-1)·tid.3d为一疗程,治疗期间停用其他药物,1个疗法结束后如未痊愈接着服第2疗程。贺波用同法治疗20例神经性尿频症.结果80％2个疗程全部治愈.NP可降低平滑肌细胞内钙离子的浓度,使逼尿肌松驰,膀胱蓄尿增多.2 小儿肺炎徐静美对30例小儿肺炎在常规治疗的同时辅用NP0.3～0.5 mg·kg~(-1)·d~(-1)·次~(-1),tid.口服或舌下含化.用至咳喘及肺部罗音消失.结果止咳平喘及肺
Nifedipine (hereinafter referred to as NP) is a calcium antagonist.It is mainly used for the treatment of coronary heart disease angina pectoris and hypertension.In recent years, its clinical application is increasing.Now in the pediatric new use of NP are as follows. Pediatric neurogenic urinary frequency Zhang Xirun and other NP treatment of pediatric neurogenic frequent urination in 40 cases, the results of a course of cure in 28 cases (70%) .2 courses were all cured. The treatment: 0.5 ~ 1.0 mg · kg ~ (-1) · d ~ (-1) · tid.3d for a course of treatment, disable other drugs during treatment, if not cured after a course of treatment followed by the second course of treatment. He Bo with the same treatment of 20 cases of neurogenic urinary frequency.Results 80% of the 2 courses of treatment were all cured.NP can reduce the concentration of calcium in smooth muscle cells, so that detrusor relaxation, increased urinary bladder.2 Children’s pneumonia Xu Jingmei right 30 cases of children with pneumonia were routinely treated with NP 0.3 ~ 0.5 mg · kg -1 · d -1 · -1, tid. Cough and lung rales disappear. Results cough and asthma and lungs