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目的探讨血管紧张素原(AGT)基因-20A/C多态性与DN关系。方法应用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)对292例T2DM患者(正常白蛋白尿组148例,微量白蛋白尿组105例,大量白蛋白尿组39例)及157名正常对照(NC)者进行AGT基因-20A/C多态性检测。结果男性大量白蛋白尿组等位基因C频率高于正常白蛋白尿组(P=0.046)。Logistic回归分析显示,携带等位基因C(OR:4.268,P=0.043,95%CI:1.044～17.447)与男性大量白蛋白尿相关。结论 AGT基因-20A/C多态性可能与浙江地区汉族人群男性T2DM患者出现大量白蛋白尿相关。
Objective To investigate the relationship between angiotensinogen (AGT) gene -20A / C polymorphism and DN. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used in 292 patients with T2DM (normal albuminuria group, 148 cases, microalbuminuria group, 105 cases, a large number of albuminuria group, 39 cases ) And 157 normal controls (NC) were detected AGT gene -20A / C polymorphism. Results The frequency of allele C in male large albuminuria group was higher than that in normal albuminuria group (P = 0.046). Logistic regression analysis showed that carrying allele C (OR: 4.268, P = 0.043, 95% CI: 1.044 ~ 17.447) was associated with a large amount of albuminuria in men. Conclusion The AGT gene -20A / C polymorphism may be associated with a large amount of albuminuria in male patients with T2DM in Han nationality in Zhejiang province.