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目的探讨慢性阻塞性肺疾病急性加重(AECOPD)患者治疗前后血IL-10、CRP等炎症因子的浓度变化及其与肺功能损害的相关性。方法采用ELISA分析30例AECOPD患者治疗前后血清IL-10、C-反应蛋白,测PaO2、FEV1、FEV1/FVC%、外周血白细胞计数和中性粒细胞百分比,分析IL-10、CRP与FEV1和FEV1/FVC%的相关性。结果在AECOPD患者中,治疗前后IL-10浓度分别为(176.5±71.0)pg/L和(219.9±105.2)pg/L,比对照组(359.3±156.1)pg/L低;治疗前后CRP浓度分别为(23.9±17.8)mg/L和(10.1±4.2)mg/L,均比对照组(6.7±1.8)mg/L高;差异均有统计学意义。IL-10浓度与FEV l%、FEV l/FVC变化呈正相关(P<0.05);CRP浓度与FEV l%、FEV1/FVC呈负相关(P<0.05)。结论AECOPD患者血IL-10浓度较对照组低,而CRP浓度较对照组高;血IL-10和CRP的浓度与肺功能损害程度相关。
Objective To investigate the changes of blood levels of IL-10, CRP and other inflammatory cytokines in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) before and after treatment and their correlation with pulmonary dysfunction. Methods Serum levels of IL-10, C-reactive protein, PaO2, FEV1, FEV1 / FVC%, peripheral blood leukocyte count and neutrophil percentage in 30 AECOPD patients before and after treatment were analyzed by ELISA. The levels of IL-10, CRP and FEV1 Correlation of FEV1 / FVC%. Results In AECOPD patients, the concentrations of IL-10 before and after treatment were (176.5 ± 71.0) pg / L and (219.9 ± 105.2) pg / L respectively, which were lower than those of the control group (359.3 ± 156.1) pg / (23.9 ± 17.8) mg / L and (10.1 ± 4.2) mg / L respectively, which were significantly higher than those of the control group (6.7 ± 1.8) mg / L, the difference was statistically significant. The concentration of IL-10 was positively correlated with FEV l% and FEV l / FVC (P <0.05). CRP concentration was negatively correlated with FEV l% and FEV1 / FVC (P <0.05). Conclusion The concentration of serum IL-10 in AECOPD patients is lower than that in control group, while the CRP concentration is higher than that in control group. The levels of IL-10 and CRP in blood are related to the degree of pulmonary dysfunction.