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特异性抗体水平低是新生儿罹患B族Ⅲ型链球菌(Ⅲ-GBS)感染的主要因素.为了评价静脉注射用免疫球蛋白(MISG)对新生儿Ⅲ-GBS感染的预防作用,作者进行了体外研究,观察加或不加MISG的新生儿血清对Ⅲ-GBS的调理吞噬活性.MISG是由cohnⅡ组分经二硫苏糖醇还原和碘乙酰胺烷基化制得.多形核白细胞(PMNL)取自成年志愿者静脉血.Ⅲ-GBS株是从1名罹患脑膜炎的新生儿脑脊液中分离
The low level of specific antibodies is a major factor in the neonatal infection of group III-B S. In order to evaluate the prophylactic effect of intravenous immunoglobulin (MISG) on neonate III-GBS infection, the authors In vitro studies to observe opsonophagocytic activity of III-GBS in neonates with or without MISG were made by reduction of cohn II components with dithiothreitol and iodoacetamide alkylations. Polymorphonuclear leukocytes ( PMNL) was obtained from venous blood of adult volunteers. The III-GBS strain was isolated from one neonatal cerebrospinal fluid suffering from meningitis