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近年来的研究表明,脂肪组织是重要的内分泌器官,能够分泌多种因子如脂联素(adiponectin)、瘦素(leptin)、抵抗素(resistin)、肿瘤坏死因子α(TNF-α)、白介素-8(IL-8)、纤溶酶原激活物抑制物-1(PAI-1)、胰岛素样生长因子-1(IGF-1)。这些因子在调节机体糖代谢、脂代谢中发挥重要作用,与肥胖、胰岛素抵抗、2型糖尿病、心血管疾病等密切相关。内脏脂肪组织在诱导糖尿病、肥胖症相关心血管疾病和其他各种代谢症发生发展过程中发挥重要作用[1]。1 visfatin的基本特点2005年Fukuhara A等[2]发现一个在内脏脂肪特异性高表达的mRNA,其cDNA片段与PBEF5‘端非编码区的基因序
In recent years, studies have shown that adipose tissue is an important endocrine organ that can secrete a variety of factors such as adiponectin, leptin, resistin, tumor necrosis factor alpha (TNF-alpha), interleukin -8 (IL-8), plasminogen activator inhibitor-1 (PAI-1) and insulin-like growth factor-1 (IGF-1) These factors play an important role in the regulation of glucose metabolism and lipid metabolism in the body and are closely related to obesity, insulin resistance, type 2 diabetes and cardiovascular diseases. Visceral adipose tissue plays an important role in the pathogenesis of diabetes, obesity-related cardiovascular diseases and other metabolic diseases [1]. 1 basic features of visfatin In 2005, Fukuhara A et al [2] found a specific high expression of visceral fat mRNA, cDNA fragment and PBEF 5 ’non-coding region of the gene sequence