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据报道生长抑素及其稳定的长效类似物通过抑制胰腺分泌和防止细胞损伤而明显改善急性胰腺炎的预后。本实验观察了生长抑素的长效类似物质 SMS—201—995对缺血再灌注的大鼠胰腺的微循环损伤和胰腺外分泌的作用,用活体荧光显微镜观察大鼠胰腺微循环情况。在缺血后2小时末的前15分钟静脉注射 SMS—201—995 50μg/kg,然后按每小时50μg/kg 静脉持续滴注,MSM—201—995可明显改善毛细血管灌注(P<0.05)和减轻毛细血管网后微静脉中白细胞和内皮细胞的相互作用,对缺血再灌注损伤胰腺有明显保护作用,另
Somatostatin and its stable long-acting analogues have been reported to significantly improve the prognosis of acute pancreatitis by inhibiting pancreatic secretion and preventing cell damage. This experiment observed the somatostatin long-acting similar substances SMS-201-995 on ischemia-reperfusion rat pancreas microcirculation damage and pancreatic exocrine role, the use of live fluorescence microscope to observe the pancreas microcirculation in rats. MSM-201-995 significantly improved capillary perfusion (P <0.05) after IV infusion of 50 μg / kg SMS-201-995 50 μg / kg intravenously in the first 15 minutes after 2 hours of ischemia, And alleviates the interaction between leucocytes and endothelial cells in capillary venous network after ischemia-reperfusion injury and has obvious protective effect on the pancreas of ischemia-reperfusion injury