Blocking NF-kB nuclear translocation leads to p53-related autophagy activation and cell apoptosis

• 作 者: Bao-Song Zhu Chun-Gen Xing Fan
• 机 构: DepartmentofGeneralSurgery,LaboratoryofAgingandNervousDiseases,DepartmentofGeneralSurgery
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2011年4期
• 关键词: 细胞凋亡 P53 自噬 激活 免疫荧光染色法 WESTERN印迹 线粒体膜电位 易位 Nuclear factor-κB SN50 Autophagy P
• 基金项目: Supported by Health Foundation of Jiangsu Province （H20 0719）, the Higher Education Foundation of Jiangsu Province （08KJB320014）, the Natural Science Foundation of Jiangsu Province （BK2008168）, Suzhou

AIM: To investigate the anti-tumor effects of nuclear factor-κB (NF-κB) inhibitor SN50 and related mechanisms of SGC7901 human gastric carcinoma cells. METHODS: MTT assay was used to determine the cytotoxic effects of SN50 in gastric cancer cell line SGC7