论文部分内容阅读
目的:通过探讨缬沙坦联合氨氯地平治疗高血压伴左心肥厚患者的疗效及对心功能的影响,为临床治疗提供依据。方法:选择2010年1月~2014年12月我院收治的高血压伴左心室肥厚患者共120例,按照随机数字表法随机分为观察组和对照组。对照组患者给予氨氯地平,观察组患者缬沙坦联合氨氯地平治疗,治疗6个月后,观察两组患者舒张压(DBP)、收缩压(SBP)、心率(HR)、室间隔厚度(IVST),左室后壁厚度(LVPWT)、左室舒张末期内径(LVDd)和左室重量指数(LVMI)。结果:治疗后,两组患者SBP、DBP和HR均较治疗前显著降低,差异有统计学意义(P<0.05);观察组患者SBP、DBP和HR均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者IVST、IVPWT、LVDd和LVMI均较治疗前显著降低,差异有统计学意义(P<0.05);观察组患者IVST、IVPWT、LVDd和LVMI均低于对照组,差异有统计学意义(P<0.05)。结论:缬沙坦联合氨氯地平治疗高血压伴左心肥厚患者,能够降低患者血压、逆转左心室肥厚,改善患者心功能,疗效优于氨氯地平单独治疗,值得临床推广应用。
OBJECTIVE: To provide basis for clinical treatment by investigating the effect of valsartan combined with amlodipine on patients with hypertension and left ventricular hypertrophy and its influence on cardiac function. Methods: A total of 120 patients with hypertension and left ventricular hypertrophy admitted to our hospital from January 2010 to December 2014 were randomly divided into observation group and control group according to the random number table method. Patients in the control group were treated with amlodipine. The patients in the observation group were treated with valsartan combined with amlodipine. After 6 months of treatment, the diastolic blood pressure (DBP), systolic blood pressure (SBP), heart rate (HR), interventricular septum thickness IVST, LVPWT, LVDd and LVMI. Results: After treatment, SBP, DBP and HR in both groups were significantly lower than those before treatment, the difference was statistically significant (P <0.05); SBP, DBP and HR in the observation group were lower than the control group, the difference was statistically significant (P <0.05). After treatment, the IVST, IVPWT, LVDd and LVMI of the two groups were significantly lower than those before treatment (P <0.05); the IVST, IVPWT, LVDd and LVMI in the observation group were lower than those in the control group Significance (P <0.05). Conclusion: Valsartan combined with amlodipine in hypertensive patients with left ventricular hypertrophy can reduce blood pressure, reverse left ventricular hypertrophy, improve cardiac function, the effect is better than amlodipine alone, it is worthy of clinical application.