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目的：探讨血管内皮生长因子（Ｖａｓｃｕｌａｒ ｅｎｄｏｔｈｅｌｉａｌ ｇｒｏｗｔｈ ｆａｃｔｏｒ，ＶＥＧＦ）是否参与脑膜瘤瘤周水肿的病理过程。方法：２０例脑膜瘤，术前头颅磁共振（ＭＲＩ）检查，计算出水肿指数，脑膜瘤标本行病理分型，采用逆转录多聚酶链反应（Ｒｔ－ＰＣＲ）检测肿瘤中ＶＥＧＦ的表达，分析瘤周脑水肿、肿瘤生长部位、肿瘤病理类型等因素与肿瘤ＶＥＧＦ表达的相关性。结果：脑膜瘤ＶＥＧＦ的表达仅与肿瘤瘤周脑水肿程度呈正相关。结论：ＶＥＧＦ可能是脑膜瘤瘤周脑水肿的一个重要因素。
Objective: To investigate whether vascular endothelial growth factor (VEGF) is involved in the pathological process of peripheral edema of meningiomas. Methods: 20 cases of meningiomas were examined by preoperative MRI, edema index and meningiomas were collected. The expression of VEGF was detected by RT-PCR, Brain edema, tumor growth sites, tumor pathological types and other factors and tumor VEGF expression. Results: The expression of VEGF in meningiomas was only positively correlated with the degree of cerebral edema in tumor. Conclusion: VEGF may be an important factor of cerebral edema in meningeomas.