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在健康和疾病两种情况下,个体间血浆胰岛素水平的变化范围是相当大的。一般认为它反映胰岛素分泌率的变化。但是,最近的研究结果表明,血浆胰岛素消失率(insulin disappeasance rate)的变化也可能起到某种作用。 作者等对稳定期内源性胰岛素的释放、转运及血浆廓清率进行研究,目的是,a)估价稳定期胰岛素的分泌率和廓清率,b)阐明血浆胰岛素达最高浓度时一些动力学参数的范围,c)将稳定期内源性胰
In both cases of health and illness, the range of variation in plasma insulin levels among individuals is quite large. It is generally believed that it reflects changes in insulin secretion rate. However, recent findings suggest that changes in plasma insulin disappearance rate may also play a role. The authors studied the release, transport and clearance of endogenous insulin during stable phase with the aim of a) assessing the steady-state insulin secretion rate and clearance rate, b) elucidating some of the kinetic parameters of plasma insulin up to the highest concentration Range, c) endogenous pancreatic phase will be stable