以聚乙二醇为致孔剂的甲壳糖吸附、缓释葡萄糖的研究

• 作 者: 李沁华 刘宇涛 邹翰 徐国凤
• 机 构: 暨南大学生物医学工程研究所
• 出 处: 暨南大学学报(自然科学与医学版)
• 发表日期: 1995年03期
• 关键词: 甲壳糖 致孔剂 葡萄糖含量 吸附量 紫外分光光度仪 吸附性能 蒽酮 药物控制释放 不可逆过程 释放量

为了获得一种具有吸附、缓释葡萄糖效果的基质材料，探讨了致孔剂聚乙二醇不同分子量和不同用量对甲壳糖吸附、缓释葡萄糖效果的影响；比较了不同葡萄糖溶液浓度对甲壳糖吸附量的影响；并用紫外分光光度仪测定了甲壳糖吸附、缓释葡萄糖的量。通过实验，选择出了最佳的致孔剂聚乙二醇的分子量为６０００，用量为８ｇ，甲壳糖吸附葡萄糖的最佳葡萄浓度为４５％，制得的甲壳糖吸附、缓释基质对葡萄糖的吸附量为２４５０ｍｇ／ｍｇ，在２４ｈ内达到对葡萄糖控制释放的要求。

In order to obtain a matrix material with adsorption and sustained release of glucose, the effects of different molecular weights and different amounts of PEG on the adsorption and release of glucose were discussed. The effects of different concentrations of glucose solution on chitosan The amount of adsorbed amount of chitosan was measured. The amount of glucose released by chitosan was measured by UV spectrophotometer. Through experiments, we choose the best porogen polyethylene glycol molecular weight of 6000, the amount of 8g, chitosan adsorption of glucose best grapes concentration of 45%, the prepared chitosan adsorption, sustained release matrix on glucose Of the adsorption capacity of 2450mg / mg, reached within 24 hours of glucose control release requirements.