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增生性瘢痕（HS）和瘢痕疙瘩（K）临床表现明显不同，为探讨瘢痕增生的机理，对17例K、55例HS及55例正常皮肤（NS）标本采用actin、bFGF及其受体flg抗体免疫组化半定量分析，结合组织学淋巴细胞、皮肤附件变化情况的动态观察。结果：K和HS早期均有许多炎性细胞浸润在残留的皮肤附件和闭塞的毛细血管周围，随着瘢痕增生，皮肤附件、淋巴细胞和毛细血管逐渐减少，但在K组滞留的时间和数量远较HS组多。bFGF和flg在三组的成纤维细胞、血管内皮细胞、单核细胞和附件上皮细胞均有表达，强度依次为：K＞HS＞NS（P＜0.01），而K组flg表达明显强于bFGF。结论：组织中残留的皮肤附件、浸润的淋巴细胞和增生的毛细血管三者互为消长，由此，促进了成纤维细胞增殖和胶原沉积，K对flg敏感性增加，可能是其侵袭性生长的重要因素。
The clinical manifestations of hypertrophic scars (HS) and keloids (K) were significantly different. To explore the mechanism of scar hyperplasia, 17 cases of K, 55 cases of HS and 55 cases of normal skin (NS) specimens using actin, bFGF and its receptor flg Semi-quantitative analysis of antibody immunohistochemistry combined with dynamic changes of histological lymphocytes and skin appendages. RESULTS: There were many infiltrating inflammatory cells around the residual skin appendages and occluded capillaries in both K and HS. As the scar proliferated, skin appendages, lymphocytes and capillaries gradually decreased, but the time and amount of retention in group K Far more than the HS group. bFGF and flg were expressed in three groups of fibroblasts, vascular endothelial cells, monocytes and Annexin epithelial cells in the order of K> HS> NS (P <0.01), while the expression of flg in K group was significantly stronger than that of bFGF . CONCLUSION: The residual dermal attachments, infiltrating lymphocytes and proliferating capillaries in the tissues are experiencing each other’s growth and decline, thereby promoting the proliferation and collagen deposition of fibroblasts. The sensitivity of K to flg is increased, possibly due to its aggressive growth The important factor.