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目的探讨手术联合循环胸腔热灌注疗法对血清及胸水中白细胞介素-2含量的影响。方法选取2015年3月至2016年5月非小细胞肺癌伴脏层胸膜侵患者30例,采用胸腔镜肺癌根治术联合循环胸腔43℃温氯化钠注射液灌注60 min,收集灌注前后血清及胸水标本,ELISA方法检测血清及胸水中白细胞介素-2含量。结果治疗前后血清、胸水中白细胞介素-2含量比较,差异未见统计学意义(P>0.05)。结论手术联合循环胸腔热灌注疗法对血清及胸水中白细胞介素-2含量的影响尚不明确,仍需进一步研究及探讨。
Objective To investigate the effects of intra-arterial thoracic thermal perfusion therapy on interleukin-2 in serum and pleural effusion. Methods Thirty patients with non-small cell lung cancer and visceral pleural invasion from March 2015 to May 2016 were selected. Thirty-six patients were treated with thoracoscopic lung cancer radical resection combined with 43 ℃ warm sodium chloride injection in the thoracic cavity for 60 min. Serum and Pleural effusion specimens, ELISA method detection of serum and pleural fluid interleukin-2 content. Results Before and after treatment, the levels of interleukin-2 in serum and pleural effusion were not significantly different (P> 0.05). Conclusion The effect of combined operation of thoracic thermal perfusion therapy on serum and pleural effusion interleukin-2 levels remains unclear and needs further study and discussion.