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目的：系统评价口服黄连素治疗室性期前收缩（PVC）的效果。方法检索 PybMed、CENTRAL、EMbase、NTIS、CNKI、VIP、万方数据库和 CBM 中所有对比口服黄连素和抗心律失常药物（AADs）治疗室性期前收缩的临床随机对照试验（RCT），同时追索纳入文献的参考文献，检索时限均为从建库至2014年5月。对符合质量标准的 RCT 进行系统评价和 Meta 分析。结果共纳入12个随机对照试验。Meta 分析的结果显示：黄连素的有效性显著高于 AADs[85%（530/627）比79%（444/561）；OR =1.47；95% CI：1.09~1.99；P <0.05]，GRADE 系统推荐分级为低级；且黄连素的不良反应发生率显著低于 AADs[11%（32/292）比21%（59/287）；OR =0.46；95% CI：0.29~0.75；P <0.01]，GRADE 系统推荐分级为低级。结论与目前传统的抗心律失常药物相比，黄连素治疗室性期前收缩的效果更好，且不良反应发生率更低。“,”Objective To assess the cyrative effect of oral berberine on prematyre ventricyalr contraction. Methods The PybMed,CENTRAL,Embase,NTIS,CNKI,VIP,Wanfang Data and CBM were retrieved with compyters for collecting random-ized controlled trials(RCT)aboyt the comparison in the cyrative effect of oral berberine and antiarrhythmic dryg(AADs)pyb-lished from database constryction to May 2014. At the same time,the reference materials of inclyded literatyre were retrieved manyally. The eligible data of RCT that meets the standard of qyality was given a systemic review and Meta-analysis. Results There were totally 12 RCT inclyded. The resylts of Meta-analysis showed that the cyrative effect of oral berberine was statistically higher than that of AADs[85%(530 / 627)versys 79%(444 / 561);OR = 1. 47;95% CI,1. 09 ~ 1. 99;P < 0. 05], and the incidence of adverse reaction of berberine was significantly lower than that of AADs[11%(32 / 292)versys 21%(59 / 287);OR = 0. 46;95% CI,0. 29 ~ 0. 75;P < 0. 01],which was recommended for low grade by GRADE system. Conclusion Compared with the traditional antiarrhythmic drygs,berberine is better for prematyre ventricyalr contraction,and the incidence of adverse reaction of berberine is less.