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目的探讨血清血管内皮生长因子(VEGF)在肿瘤患者诊治中的临床意义及血红蛋白(Hb)浓度与VEGF水平间的关系。方法采用酶联免疫吸附法检测未经任何治疗的肿瘤患者血清VEGF浓度,同时常规检测患者Hb浓度。结果胃癌肺癌和结肠癌等肿瘤患者血清VEGF较正常对照差异有统计学意义(P<0.01),肿瘤患者Hb含量与血清VEGF浓度呈正相关。(r=-0.289,P<0.01)。低Hb(<123.5g/L)水平组肿瘤患者血清VEGF含量(695±572)ng/L,与高Hb(>123.5ng/L)组[(424±358)ng/L]比较,差异有统计学意义(P<0.05)。28例手术前Hb浓度正常(>110g/L)的患者,17例手术后Hb低于正常者,其中13例术后血清VEGF升高,11例手术后1周Hb正常者只有3例,血清VEGF浓度较术前高,两组差异有统计学意义(P>0.05)。结论血清VEGF有可能成为肿瘤辅助诊断的指标,低Hb浓度很可能是患者血清VEGF升高的诱因,及时纠正肿瘤患者低Hb含量,有可能是预防血清VEGF水平升高的有效途径之一。
Objective To investigate the clinical significance of serum vascular endothelial growth factor (VEGF) in the diagnosis and treatment of cancer patients and the relationship between the concentration of hemoglobin (Hb) and the level of VEGF. Methods Serum levels of VEGF were measured by enzyme-linked immunosorbent assay (ELISA) in patients with cancer without any treatment, and Hb concentration was routinely tested. Results There was significant difference in serum VEGF between gastric cancer patients with lung cancer and colon cancer patients (P <0.01). Hb content in cancer patients was positively correlated with serum VEGF concentration. (r = -0.289, P <0.01). The level of serum VEGF in patients with low Hb (<123.5g / L) was significantly higher than that in patients with high Hb (> 123.5ng / L) [(424 ± 358) ng / L] Statistical significance (P <0.05). Of the 28 patients with normal Hb concentrations (> 110g / L) before surgery, 17 had Hb levels lower than normal after surgery, 13 of whom had elevated serum VEGF after surgery. Only 3 of the 11 patients had normal Hb at 1 week after operation, The concentration of VEGF was higher than that before operation, the difference was statistically significant (P> 0.05). Conclusions Serum VEGF may be an indicator of adjuvant tumor diagnosis. Low Hb concentration may be the cause of elevated serum VEGF in patients. Correcting the low Hb level in patients with tumor may be one of the effective ways to prevent the increase of serum VEGF.