Association of Preoperative Serum IGF-Ⅰ Concentration with Clinicopathological Parameters in Patient

• 作 者: 付圣灵 唐和孝 廖永德 江文洋 徐沁孜 邓豫 付向宁
• 机 构: Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Scie
• 出 处: Journal of Huazhong University of Science and Technology(Med
• 发表日期: 2013年02期
• 关键词: progression Serum endocrine prognosis metastasis preoperative immunosorbent wors

Insulin-like growth factor-Ⅰ (IGF-Ⅰ) is a mitogenic and anti-apoptotic factor. Serum IGF-I concentration is related to some cancer risk and tumor progression. The aim of this research was to study the association of preoperative serum IGF-Ⅰ concentration with clinicopathological parameters and prognosis of non-small cell lung cancer (NSCLC). Preoperative serum IGF-Ⅰ concentration was measured in 80 consecutive patients with NSCLC who underwent radical lung cancer resection, and 45 patients with benign pulmonary lesion (BPL) by using enzyme linked immunosorbent assay (ELISA). The results showed that the serum IGF-Ⅰ concentration was elevated and correlated with clinicopathological parameters and overall survival (OS) in NSCLC patients. Serum IGF-Ⅰ concentration was significantly higher in patients with NSCLC than in those with BPL. The IGF-Ⅰ concentrations were significantly higher in NSCLC patients with ≥T2, N1-3, and in ⅢA-Ⅳ but not in those with