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早在60年代De Wied就报道了加压素对记忆巩固的易化作用,近年来我们又报道了加压素对学习过程的增强作用,但它的作用机制至今尚未阐明.我们实验室的工作表明,AVP对学习过程的增强作用主要是通过它对海马、隔核和杏仁等边缘系统核团功能的调节来实现的.我们还报道了AVP对海马脑电节律和单位放电的影响.另有工作报道,AVP可直接兴奋隔核的神经元,对隔区脑片的LTP的维持起着重要的作用,在海马内可能起着递质的作用.为了探讨AVP增强学习记忆的作用机制,本工作在大鼠海马脑片CA1区研究了AVP对LTP的作用.
As early as the 1960s, De Wied reported the facilitatory effect of vasopressin on memory consolidation. In recent years, we report the enhancement effect of vasopressin on the learning process, but its mechanism of action has not been elucidated yet. The work of our laboratory Shows that AVP enhances the learning process mainly through its regulation of the nucleus functions of the limbic system such as hippocampus, septal nucleus and almond.We also reported the effect of AVP on hippocampal EEG and unit discharge. It has been reported that AVP can directly excite nucleus neurons and plays an important role in the maintenance of LTP in segmental brain slices and may play a role in neurotransmitter in hippocampus.In order to investigate the mechanism of AVP enhancing learning and memory, Working in rat hippocampal slices of CA1 area of AVP on the role of LTP.