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多年来,纹状体被认为是安定剂抗动物定型活动效应的重要靶组织。但脑内注射研究发现,多数安定剂抑制拟多巴胺(DA)的诱发效应所需剂量常常接近于外周注射有效剂量,因而对此假说有异义。纹状体内注射安定剂呈现弱效应可能有两种因素:1)大多数经典安定剂为高亲脂性,使之迅速扩散离开注射部位;2)纹状体只有局限的部位注射才有抗定型效应。因此局部注射的精确定位很重要。许多研究证明,纹状体是一个
For years, striatum has been identified as an important target tissue against the effects of stabilizers on animal stereotyping. However, an intracerebral injection study found that most diastolic agents often have a dose-effect similar to that of peripherally injected injections to inhibit the induction effect of dopamine (DA), and therefore have a different meaning. There are two possible reasons for the weak effect of striatal injectable transtuds: 1) Most classical stabilizers are highly lipophilic, allowing them to rapidly diffuse out of the injection site; 2) Striatum has an anti-styling effect only in localized sites . Therefore, the precise positioning of the local injection is very important. Many studies have shown that the striatum is one