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目的检测早产儿血清中基质金属蛋白酶-16(MMP-16),NF-κB水平的变化,探讨其与支气管肺发育不良的关系。方法:留取2010年1月~2013年12月在江苏大学附属医院分娩胎龄≤35周的早产儿血清作为实验组,采用酶联免疫吸附法检测血清中MMP-16、NF-κB表达水平,随访BPD发生率,回顾性分析MMP-16、NF-κB与BPD的关系。结果:早产儿中发生支气管肺发育不良患儿血清中MMP-16,NF-κB表达水平明显高于未发生支气管肺发育不良患儿,差异具有统计学意义(P<0.01),早产儿发生支气管肺发育不良患儿血清中MMP-16和NF-κB呈直线正相关关系,差异具有统计学意义(P<0.01)。结论:通过检测早产儿血清中MMP-16和NF-κB的水平,对于早期发现和治疗BPD,降低其并发症等具有重要的临床意义。
Objective To detect the changes of serum matrix metalloproteinase-16 (MMP-16) and NF-κB levels in preterm infants and explore their relationship with bronchopulmonary dysplasia. Methods: Serum samples of premature neonates with gestational age ≤35 weeks from January 2010 to December 2013 in our hospital were enrolled in this study. Serum levels of MMP-16 and NF-κB were measured by enzyme-linked immunosorbent assay The incidence of BPD was followed up. The relationship between MMP-16, NF-κB and BPD was analyzed retrospectively. Results: Serum levels of MMP-16 and NF-κB in preterm infants with bronchopulmonary dysplasia were significantly higher than those without bronchopulmonary dysplasia (P <0.01). Premature infants had bronchial There was a linear positive correlation between serum MMP-16 and NF-κB in children with lung dysplasia, the difference was statistically significant (P <0.01). Conclusion: Detecting serum levels of MMP-16 and NF-κB in preterm infant has important clinical significance for the early detection and treatment of BPD and its complications.