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人T-淋巴细胞受体(TCR)是由免疫球蛋白样异二聚体组成的分子复合物,称为Tiα/β,具有特异性抗原识别能力,其单体型多肽亚单位分为γ、δ,ε和ζ型,并推测它涉及穿膜信号。Preyious证实在α-和β-恒定区Ti基因附近存在限制性片段长度多态性(RFLP),同时认为特异性等位基因RFLP与某些自身免疫性疾病相关联。作者观察到CD_3-ε基因也显示双等位基因RFLP,因此分析了与青年型类风湿关节炎(JRA)和胰岛素依赖性糖尿病(IDDM)易感性的相关
Human T-lymphocyte receptor (TCR) is a molecular complex composed of immunoglobulin-like heterodimers, called Tiα / β, which has the ability of specific antigen recognition. The monomeric polypeptide subunits are divided into γ, δ, ε and ζ, and speculate that it involves transmembrane signals. Preyious demonstrated that there was a restriction fragment length polymorphism (RFLP) near the Ti gene in the α-and β-constant regions and that the specific allele RFLP was associated with certain autoimmune diseases. The authors observed that the CD_3-ε gene also showed a biallelic RFLP and thus analyzed the association with susceptibility to juvenile rheumatoid arthritis (JRA) and insulin-dependent diabetes mellitus (IDDM)