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目的 :调查广西慢性肝炎、肝硬化及原发性肝癌患者中的丙型肝炎病毒 (HCV)感染状况及 HCV基因型别 ,评价 HCV感染在上述肝病发病中的作用。方法 :用第 2代酶免疫试剂盒检测患者的抗 - HCV抗体 ,阳性者再用型特异 PCR方法检测HCV基因型。结果 :186例原发性肝癌、 38例慢性迁延性肝炎、 30例慢性活动性肝炎、 5 0例肝硬化及 48例健康成人抗 - HCV检出率依次为 2 .15 % ,5 .2 6 % ,6 .6 7% ,2 .0 %和 0 ,各组间差异无显著性 (P>0 .0 5 )。对 9例抗 - HCV阳性病例进行 HCV基因分型 ,结果全部为 型 ,其中 2例同时伴有 型感染。结论 :广西慢性肝炎、肝硬化及原发性肝癌患者中 HCV感染比例较低 ,主要为 型感染。 HCV在广西慢性肝炎、肝硬化、原发性肝癌发病中所起作用可能相对较小。
Objective: To investigate the status of hepatitis C virus (HCV) and HCV genotypes in patients with chronic hepatitis, cirrhosis and primary liver cancer in Guangxi and to evaluate the role of HCV infection in the pathogenesis of the above liver diseases. Methods: The anti-HCV antibodies of patients were detected by the second generation of enzyme immunoassay kit. The HCV genotypes were detected by specific PCR. Results: The detection rates of anti-HCV in 186 cases of primary liver cancer, 38 cases of chronic persistent hepatitis, 30 cases of chronic active hepatitis, 50 cases of cirrhosis and 48 cases of healthy adults were 2.15% and 5.26 %, 6.7%, 2.0% and 0 respectively. There was no significant difference between the groups (P> 0.05). HCV genotyping was performed on 9 anti-HCV positive cases, all of which were typed, of which 2 were concurrently infected. Conclusion: The proportion of HCV infection in chronic hepatitis, cirrhosis and primary hepatocellular carcinoma in Guangxi is low, mainly of type infection. HCV may play a relatively minor role in the pathogenesis of chronic hepatitis, cirrhosis and primary liver cancer in Guangxi.