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目的:探讨促血管生成素2(angiopoietin-2,Ang2)基因1087G/A位点基因多态性与卵巢癌的关系。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对158例卵巢癌患者和160例健康对照者的Ang2基因1087G/A位点基因型进行检测。结果:Ang2基因1087G/A位点基因型频率和等位基因频率在两组人群中的分布差异无统计学意义(P>0.05)。结论:Ang2基因1087G/A位点基因多态性可能与卵巢癌发生无关。
Objective: To investigate the relationship between the 1087G / A gene polymorphism of angiopoietin-2 (Ang2) gene and ovarian cancer. Methods: The genotypes of 1087G / A of Ang2 gene in 158 patients with ovarian cancer and 160 healthy controls were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The distribution of genotype frequency and allele frequency of Ang7 gene at 1087G / A locus was not statistically different between the two groups (P> 0.05). Conclusion: The gene polymorphism of Ang7 1087G / A may not be related to the occurrence of ovarian cancer.