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目的探讨喉鳞状细胞癌(LSCC)组织中肿瘤转移相关蛋白S100A4的表达及临床意义。方法采用免疫组织化学EliVision二步法检测S100A4蛋白在42例LSCC组织、20例癌旁正常黏膜组织中的表达并分析其与LSCC临床病理特征的关系。结果①S100A4蛋白在42例LSCC组织中的阳性表达率为31.0%,而在20例癌旁正常黏膜组织中未见阳性表达,两者差异有统计学意义(P<0.01)。②淋巴结转移组S100A4蛋白阳性表达率(50.0%)高于无淋巴结转移组(13.6%),在临床分期中Ⅲ+Ⅳ期S100A4蛋白阳性表达率(44.0%)高于Ⅰ+Ⅱ期(11.8%),差异均有统计学意义(P<0.05);S100A4蛋白在LSCC中的表达与年龄、性别、原发部位、组织学分化程度及T分期无关(均P>0.05)。结论 S100A4蛋白在LSCC的发生、发展中可起重要作用,可作为预测LSCC发生及侵袭转移潜能的参考指标之一。
Objective To investigate the expression and clinical significance of tumor metastasis-associated protein S100A4 in laryngeal squamous cell carcinoma (LSCC). Methods The expression of S100A4 protein in 42 LSCC tissues and 20 adjacent normal mucosa tissues was detected by immunohistochemical EliVision two-step method and its relationship with clinicopathological features of LSCC was analyzed. Results ① The positive expression rate of S100A4 protein in 42 LSCC tissues was 31.0%, while it was not found in 20 adjacent normal mucosa tissues, the difference was statistically significant (P <0.01). ② The positive rate of S100A4 protein in lymph node metastasis group (50.0%) was higher than that in non-lymph node metastasis group (13.6%). The positive rate of S100A4 protein in stage Ⅲ + Ⅳ was higher than that in stage Ⅰ + Ⅱ (11.8% ), The difference was statistically significant (P <0.05). The expression of S100A4 protein in LSCC was not related to age, sex, primary site, histological differentiation and T stage (all P> 0.05). Conclusion S100A4 protein may play an important role in the occurrence and development of LSCC and may serve as a reference index for predicting the occurrence and metastasis potential of LSCC.