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采用荧光法测定６１ 例孕晚期妊高征患者，２０ 例同期正常孕妇产前、产后２４ ｈ 外周血血小板细胞内游离钙离子浓度、血清钙浓度及尿蛋白含量，同时以１５ 例健康非孕妇女作对照。结果发现，妊高征患者血小板细胞内游离钙离子浓度明显高于正常孕妇及非孕妇女（ Ｐ＜ ０．０１）；产后２４ｈ 妊高征患者血小板细胞内游离钙离子浓度明显低于产前，高于正常孕妇及对照组（ Ｐ＜ ０．０５）；中、重度妊高征患者血小板细胞内游离钙离子浓度与其血压及尿蛋白呈正相关（ｒ 分别为０５、０６、０９３、０９２， Ｐ＜ ００１）；妊高征患者血清钙浓度明显低于正常孕妇及健康非孕妇女（ Ｐ＜ ０．０１）。提示细胞内游离钙离子浓度与妊高征的发生与发展密切相关，可能是导致妊高征血压升高、蛋白尿形成的重要因素
Sixty-one patients with PIH during pregnancy in the third trimester of pregnancy and 20 normal pregnant women at the same period were tested for intracellular free calcium concentration, serum calcium concentration and urinary protein content in pre-natal and post-natal group at 24 hours. Meanwhile, 15 healthy non-pregnant women As a control. The results showed that the intracellular free calcium concentration in platelet of patients with PIH was significantly higher than that of normal pregnant women and non-pregnant women (P <0.01). The intracellular free calcium concentration of platelets in PIH patients was significantly lower than that of prenatal, (P <0.05). The levels of intracellular free calcium in platelet of patients with moderate and severe pregnancy-induced hypertension were positively correlated with blood pressure and urinary protein (r = 0.5,0.6,0.0 93,092, P <001). Serum calcium concentration in patients with PIH was significantly lower than that in normal pregnant women and healthy non-pregnant women (P <0.01). It is suggested that intracellular free calcium concentration is closely related to the occurrence and development of PIH, which may be an important factor in the pathogenesis of PIH and the formation of proteinuria