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心肌血管再造的病人在冠状动脉搭桥手术后出现再灌注损伤。临床上证明缺氧心脏再通氧时,氧自由基损伤细胞。持续缺血后恢复动脉灌注,会引起结构、功能以及生化性损伤,并常引起术后心律失常,使患者死亡。研究认为,再灌注损伤可能是由于过氧化物阴离子产生过多,使细胞膜上多价未饱和脂质过氧化造成的,该过程的起动因素是高度细胞毒性和反应活性的羟基。牛磺酸可以调节肌纤维膜上的Ca~(2+)通道,具有抗氧化、消除自由基等功能,所以可以保护心肌细胞。本文作者研究牛磺酸对自由基的消除作用。对象和方法:准备做冠状动脉搭桥术的稳定型心绞痛12例男性患者,病人符合下列条件:射血分数正常(52%±8%);最近4周内无心肌梗死发作;搭桥手术中血管再造良好;年龄30～60岁。将病人
Patients with myocardial revascularization have a reperfusion injury after coronary artery bypass graft surgery. Clinically proven oxygen reoxygenation heart, oxygen free radicals damage cells. Continuous ischemia and recovery of arterial perfusion can cause structural, functional, and biochemical damage and often cause postoperative arrhythmias that kill the patient. Studies suggest that reperfusion injury may be due to excessive production of peroxide anion, the membrane of the polyunsaturated lipid peroxidation caused by the process of starting a highly cytotoxic and reactive hydroxyl. Taurine can regulate the Ca ~ (2+) channel on the muscle fiber membrane, and has the functions of anti-oxidation and elimination of free radicals, so it can protect the myocardial cells. The author of this study taurine on the elimination of free radicals. PARTICIPANTS AND METHODS: Twelve male patients with stable angina pectoris undergoing coronary artery bypass grafting were eligible for the following conditions: ejection fraction normal (52% ± 8%); absence of myocardial infarction in the last 4 weeks; revascularization in bypass surgery Good; age 30 to 60 years old. Will the patient