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目的探讨痰热清注射液治疗儿童阻塞性睡眠呼吸暂停低通气综合征(OSAHS)疗效及对血清瘦素水平的影响。方法选取2014年1月至2015年6月于该院接受治疗的140例OSAHS患儿作为研究对象,随机分为对照组70例和观察组70例。常规治疗基础上,对照组患儿给予无创正压通气治疗,而观察组患儿在对照组基础上给予痰热清注射液治疗。比较两组患儿临床症状改善情况、呼吸暂停通气不足指数(AHI)、平均血氧饱和度(MSaO_2)、最低动脉血氧饱和度(LSaO_2)、睡眠中SaO_2<90%持续时间占总睡眠时间百分比(TS90%)及血清瘦素水平。结果治疗后,与对照组相比,观察组患儿睡眠打鼾、张口呼吸、夜间憋醒、白天嗜睡等临床症状发生率明显降低(8.6%vs.21.4%,7.1%vs.18.6%,4.3%vs.14.3%,5.7%vs.17.1%),AHI、MSaO_2、LSaO_2、TS90%等指标改善更明显[(16.2±2.3)vs.(19.5±3.7)次/小时,(97.1±5.8)%vs.(94.8±4.5)%,(83.9±7.1)%vs.(80.7±6.4)%,(7.3±1.5)%vs.(9.2±1.6)%],血清瘦素水平显著下降[(5.14±1.06)ng/mL vs.(6.10±1.25)ng/mL],组间比较差异均有统计学意义(P<0.05)。结论痰热清注射液辅助治疗儿童OSAHS疗效可靠,能够明显改善临床症状,降低AHI,提高血氧饱和度,并且能够显著降低血清瘦素水平,临床上值得进一步研究。
Objective To investigate the therapeutic effect of Tanreqing injection on childhood obstructive sleep apnea-hypopnea syndrome (OSAHS) and its effect on serum leptin level. Methods From January 2014 to June 2015, 140 children with OSAHS treated in our hospital were selected as study subjects and randomly divided into control group (70 cases) and observation group (70 cases). On the basis of routine treatment, the control group received noninvasive positive pressure ventilation while the observation group was given Tanreqing Injection on the basis of the control group. The improvement of clinical symptoms, apnea-hypopnea index (AHI), mean arterial oxygen saturation (MSaO_2) and minimum arterial oxygen saturation (LSaO_2) in both groups were compared, and the duration of sleep <90% Percentage (TS90%) and serum leptin levels. Results After treatment, the incidence of clinical symptoms such as sleep snoring, mouth breathing, nighttime arousal and daytime sleepiness were significantly decreased in the observation group compared with the control group (8.6% vs.21.4%, 7.1% vs.18.6%, 4.3% vs.14.3%, 5.7% vs.17.1%). The AHI, MSaO_2, LSaO_2, TS90% and other indexes improved more significantly (16.2 ± 2.3 vs. 19.5 ± 3.7) / (97.1 ± 5.8)% vs (94.8 ± 4.5)%, (83.9 ± 7.1)% vs (80.7 ± 6.4)%, (7.3 ± 1.5)% vs (9.2 ± 1.6)%, respectively ) ng / mL vs. (6.10 ± 1.25) ng / mL, respectively. There was significant difference between the two groups (P <0.05). Conclusion Tanreqing injection adjuvant treatment of children OSAHS reliable curative effect, can significantly improve clinical symptoms, reduce AHI, increase oxygen saturation, and can significantly reduce the serum leptin levels, the clinical worth further study.