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最近,在早至孕4.5周的人胎儿脑组织中鉴定出了免疫反应的促黄体生成素释放激素(LH-RH)。作者在本研究中,进一步用放射免疫测定来确定在人胎儿的下丘脑及脑皮质组织中LH-RH的存在,并检查这些提取物当注射进适当处理过的切卵巢大鼠的颈动脉中时释放促性腺激素的活性。作者收集16个中期的人胎儿,头臀长为46～179毫米,所有胎儿均在子宫切开5～10分钟内自子宫取出。按Iffy等的表格查头臀长及体重以决定胎龄。根据内、外生殖器的肉眼及组织学检查来决定胎儿性别。取出的下丘脑和额叶皮质的组织样
Recently, immunoreactive luteinizing hormone releasing hormone (LH-RH) has been identified in human fetal brain tissue as early as 4.5 weeks pregnant. In the present study, the authors further determined by radioimmunoassay the presence of LH-RH in hypothalamus and cortex tissues of human fetuses and examined these extracts when injected into the carotid artery of appropriately treated ovariectomized rats Gonadotropin releasing activity. The authors collected 16 metaphase human fetuses with a head-to-tail length of 46 to 179 mm. All fetuses were removed from the uterus within 5 to 10 minutes of incision in the uterus. According to Iffy and other forms to check the head length and weight to determine the gestational age. According to the internal and external genital eye and histological examination to determine the fetal sex. Tissues of the hypothalamus and frontal cortex removed