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目的 研究 2型糖尿病微量白蛋白尿患者血浆血小板活化因子 (PAF)的水平及其与尿白蛋白排泄率 (UAER)的相互关系。方法 采用生物学方法和放免法分别测定 30例健康人(正常对照组)、30例 2型糖尿病正常白蛋白尿患者、28例 2型糖尿病微量白蛋白尿患者血浆PAF和UAER水平。结果 (1)正常对照组与正常白蛋白尿组相比UAER、血浆PAF均无显著性差异(P>0. 05); (2)在排除代谢因素影响后, 2型糖尿病组中微量白蛋白尿组与正常白蛋白尿组相比血浆PAF有非常显著性差异(P<0. 01); (3)UAER与PAF正相关,相关系数 0. 68,尤其在微量白蛋白尿组,相关系数达 0. 74。结论 血浆PAF增高可能参与了 2型糖尿病微量白蛋白尿的发生、发展过程,它的检测可作为早期糖尿病肾病的诊断、治疗、预后观察的一个临床指标。
Objective To investigate the relationship between plasma platelet-activating factor (PAF) and urinary albumin excretion (UAER) in type 2 diabetic patients with microalbuminuria. Methods The levels of plasma PAF and UAER in 30 healthy subjects (control group), 30 normal type 2 diabetic patients with albuminuria and 28 type 2 diabetic patients with microalbuminuria were measured by biological methods and radioimmunoassay. Results (1) There was no significant difference between UAER and plasma PAF in normal control group and normal albuminuria group (P> 0.05). (2) After excluding the influence of metabolic factors, microalbuminuria Urine group compared with normal albuminuria plasma PAF has a very significant difference (P <0.01); (3) UAER and PAF positive correlation, correlation coefficient 0.68, especially in the microalbuminuria group, the correlation coefficient Up to 0.74. Conclusion The increase of plasma PAF may be involved in the occurrence and development of type 2 diabetes microalbuminuria, and its detection may be used as a clinical indicator in the diagnosis, treatment and prognosis of early diabetic nephropathy.