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在恶性血液病化疗后的骨髓抑制期,感染成为其主要并发症并常导致病人的死亡,尤其是深部真菌感染,越来越显现出其杀手本色。尽管尸检表明在此类患者深部真菌感染的机会高达25～35％,但临床资料并不能为早期诊断提供足够的证据,比如血液或分泌物真菌培养多为阴性,因而经验用药在此时显得很有用。对于骨髓抑制期的粒细胞缺乏病人,临床上较为常用的抗真菌指征是广谱抗生素无效的持续发热或退热后再度反复。资料表明:两性霉素
During the myelosuppression after chemotherapy for hematologic malignancies, infection becomes a major complication and often leads to the death of patients, especially deep fungal infections, which increasingly show their killer character. Although autopsy shows a 25-35% chance of deep fungal infection in such patients, clinical data do not provide sufficient evidence for early diagnosis, such as more negative cultures of blood or secretions of fungi, and experience medication appears to be significant at this time it works. For myelosuppressive patients with agranulocytosis, clinical indications for anti-fungi are broad-spectrum antibiotics ineffective continuous fever or fever again after repeated. Data show: amphotericin