论文部分内容阅读
Objective To study the clinical and histological features of chronic hepatitis B (CHB) with negative hepatitis B e-antigen (HBeAg).Methods A tatal of 743 in-patients with chronic hepatitis B were recruited into the study and divided into two groups according to the HBeAg status. The correlation among alanine transaminase (ALT) levels, hepatitis B virus (HBV) DNA semiquantification, and the liver histopathological data were dectected.Results Of the 743 successive in-patients, 267 (35.9%) were HBeAg-negative. The HBDAG-negative group had significantly lower serologic HBV DNA levels (63.0% of < 100 pg/ml) vs HBeAg-positive (42.6%, P<0. 001), while more sever inflammation (58. 1% of inflammatory scores of histological activeity index (HAIinf≥9) vs HBeAg-positive group (46.0%, P< 0.001) and severe fibrosis (45.3% of fibrosis scores of histological activity index (HAIfib≥3) vs HBeAg-positive group (27.9%, P < 0. 001 ) of liver histology. In HBeAg-positive patients, increasing ALI levels were significantly a
Objective To study the clinical and histological features of chronic hepatitis B (CHB) with negative hepatitis B e-antigen (HBeAg). Methods A tatal of 743 in-patients with chronic hepatitis B were were recruited into the study and divided into two groups according to The correlation among alanine transaminase (ALT) levels, hepatitis B virus (HBV) DNA semiquantification, and the liver histopathological data were dectected. Results of the 743 successive in-patients, 267 (35.9%) were HBeAg- negative. The HBDAG-negative group had significantly lower serologic HBV DNA levels (63.0% of <100 pg / ml vs HBeAg-positive (42.6%, P <0.001, while more sever inflammation histological activeity index (HAIinf≥9) vs HBeAg-positive group (46.0%, P <0.001) and severe fibrosis (45.3% of fibrosis scores of histological activity index 0. 001) of liver histology. In HBeAg-positive patients, increasing ALI levels were significantly a