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为研究复方丹参滴丸治疗高粘滞血症的机制 ,采用肾上腺素 (0 .1% ) 0 .5 mg/ kg sc,高分子右旋糖酐生理盐水注射液 (10 % ) 0 .6 g/ kg快速尾 iv造成急性高粘滞血症模型。治疗药物用复方丹参滴丸 ,用药量 15 mg/ kg体重(成人用量 5倍 )为丹低组、用药量 30 mg/ kg体重 (成人用量 10倍 )为丹中组、用药量 75 mg/ kg体重 (成人用量 2 5倍 )为丹高组 ,造模前 90 min ig 1次。造模 6 0 min后股动脉取血 ,检测红细胞变形能力。结果发现 :复方丹参滴丸具有改善急性高粘滞血症模型鼠红细胞变形能力的作用 ,而且在 15～ 75 mg/ kg体重剂量范围内 ,随剂量增加 ,疗效递增
To study the mechanism of compound Danshen Dripping Pills in treating hyperviscosity, epinephrine (0.1%) 0.5 mg/kg sc, polymer dextrose saline (10 %) 0.6 g/kg fast Tail iv caused an acute hyperviscosity model. Compound Danshen Dripping Pills for therapeutic drugs, 15 mg/kg body weight (5 times adult dose) for Danlow group, 30 mg/kg body weight (10 times adult dose) for Danzhong group, 75 mg/kg dose The body weight (25 times adult dosage) was Dan Gao group, which was ig 90 min before the model was built. Sixty minutes later, blood was collected from the femoral artery to determine red blood cell deformability. Findings: Compound Danshen Dripping Pills have the effect of improving the red blood cell deformability of model rats with acute hyperviscosity, and within the dose range of 15 to 75 mg/kg body weight, the therapeutic effect increases as the dose increases.