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目的 探讨心肌肌钙蛋白I(cTnI)在急性一氧化碳中毒 (ACOP)患者心肌损伤诊断中的意义。方法 3 0例本院轻度 (n =14 )及中度 (n =16)ACOP患者 ,检测接诊后 0h、8h、1d、3d及 7d时血清cTnI水平、心肌酶学及心电图 ,比较cTnI和其他单项或综合指标对轻度及中度ACOP患者心肌损伤检出率的差异。结果 中度中毒组cTnI升高例数显著高于轻度中毒组 (P <0 0 1) ,其他各单项指标异常例数的差异无显著性 (P >0 0 5 ) ;两组间心肌酶学升高或心电图异常例数的差异无显著性 (P >0 0 5 ) ;综合心肌酶学及心电图检查结果后 ,中度中毒组检出例数显著高于轻度中毒组 (P <0 0 5 )。cTnI升高的例数显著高于单一或综合指标异常的例数 (P <0 0 5 )。结论 应用血清cTnI的检测能提高ACOP患者心肌损伤的检出率 ,其灵敏度明显优于心肌酶学及心电图检查。
Objective To investigate the significance of cardiac troponin I (cTnI) in the diagnosis of myocardial injury in patients with acute carbon monoxide poisoning (ACOP). Methods Thirty (30) mild ACOP patients (n = 14) and moderate (n = 16) ACOP patients were enrolled in this study. Serum levels of cTnI, myocardial enzymes and electrocardiogram were measured at 0h, 8h, 1d, 3d and 7d after admission. And other single or comprehensive indicators of mild and moderate ACOP patients with myocardial injury detection rate differences. Results The number of elevated cTnI in moderate poisoning group was significantly higher than that in mild poisoning group (P <0.01). There was no significant difference in the number of abnormalities among the other individual indexes (P> 0.05) There was no significant difference between the two groups (P> 0.05). There was no significant difference in the number of cases of abnormal or abnormal electrocardiogram (P> 0.05). The results of comprehensive myocardial enzymology and electrocardiogram showed that the number of moderate poisoning group was significantly higher than that of mild poisoning group 0 5). The number of patients with elevated cTnI was significantly higher than those with single or composite abnormalities (P <0.05). Conclusion The detection of serum cTnI can improve the detection rate of myocardial injury in ACOP patients, and its sensitivity is better than that of myocardial enzymology and electrocardiogram.