论文部分内容阅读
已报道,用d,l-多乳酸聚合物造成的生物降解微球,在给灵长类单次注射后,能持续释放炔诺酮6或3个月。血液炔诺酮水平与剂量相关。较低剂量对卵巢机能无明显影响,而较高剂量则可维持炔诺酮水平达到足以抑制排卵直到6个月。本文报道了使用无抑制排卵作用剂量的长效炔诺酮微囊系统对生育力的影响。使用的微球系统含20%的炔诺酮,直径从100～125μm,在单次肌肉注射后可持续释放炔诺酮3个月。基于曾证明,含25～100mg炔诺酮的微囊可以使正常狒狒的月经周期,内源性卵巢甾体的产生
It has been reported that biodegradable microspheres made of d, l-polylactic acid polymer sustained release of norethindrone for 6 or 3 months after single injections into primates. Blood norethindrone levels were dose-related. Lower doses had no significant effect on ovarian function, whereas higher doses maintained norethindrone levels sufficiently to suppress ovulation until 6 months. This article reports the effect of long-acting norethindrone microcapsule systems on fertility using a dose that does not inhibit ovulation. The microsphere system used contains 20% norethindrone, ranging in diameter from 100 to 125 μm, and sustained release of norethindrone for 3 months after a single intramuscular injection. Based on the evidence that microcapsules containing 25 to 100 mg of norethindrone, the normal menstrual cycle of baboons, the production of endogenous ovarian steroids