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目的探讨Ⅰb～Ⅱb期宫颈癌术前介入化疗栓塞的临床疗效及病理学改变。方法对2005年1月至2009年1月在我院就诊的55例宫颈癌患者实施术前动脉介入化疗,抗癌药物为顺铂、表阿霉素、5-Fu,灌注化疗后用明胶海绵颗粒栓塞肿瘤供血动脉。结果55例宫颈癌患者经1～2次术前介入化疗后顺利手术切除,术后标本病理切片中可见大量坏死组织及淋巴细胞浸润,其中组织学完全缓解8例。结论宫颈癌术前介入化疗栓塞可有效缩小肿瘤体积,减少术中出血,部分患者可达到组织学完全缓解的效果。
Objective To investigate the clinical efficacy and pathological changes of preoperative chemoembolization in stage Ⅰb ~ Ⅱb cervical cancer. Methods 55 cases of cervical cancer patients treated in our hospital from January 2005 to January 2009 underwent preoperative arterial interventional chemotherapy. The anticancer drugs were cisplatin, epirubicin and 5-Fu. After the infusion chemotherapy, gelatin sponge Particle embolization of tumor feeding artery. Results Fifty-five patients with cervical cancer were successfully surgically removed after one or two preoperative interventions. A large number of necrotic tissues and lymphocytes infiltrated in the pathological sections of the specimens, of which histological complete remission was achieved in 8 cases. Conclusion The preoperative interventional chemotherapy and embolization of cervical cancer can effectively reduce the tumor volume and reduce intraoperative bleeding, and some patients can achieve the effect of complete remission of histology.