Chemoselective synthesis of novel aminoindolizines using aminopyridines, acetylenic diesters and α-h

• 作 者: Sakineh Asghari Mohammad Qandalee Vahideh Behboodi Arastoo Nouri Gorji Ghasem Firouzzade Pash
• 机 构: Department of Organic Chemistry,Faculty of Chemistry,University of Mazandaran,Nano and Biotechnology
• 出 处: Chinese Chemical Letters
• 发表日期: 2016年03期
• 关键词: skeleton dimethylamino pyridine carbonyl ketone bromide heterocyclic moiety spec

A chemoselective synthesis of novel indolizine derivatives were reported via three-component reactions of aminopyridines, acetylenic diesters and a-halo ketones. In these reactions, the zwitterion generated from aminopyridines and acetylenic diesters reacted with a-halo ketones to produce indolizine skeleton in good to high yields under mild reaction conditions.

A chemoselective synthesis of novel indolizine derivatives were reported via three-component reactions of aminopyridines, acetylenic diesters and a-halo ketones. In these reactions, the zwitterion generated from aminopyridines and acetylenic diesters reacted with a-halo ketones to produce indolizine skeleton in good to high yield under mild reaction conditions.