Synthesis and Anti-tumor Activity of Novel Glycyrrhetinic Acid Derivatives

• 作 者: MENG Yan-qiu DING Jia-qi LIU Y
• 机 构: DepartmentofPharmaceuticalEngineering,DepartmentofPharmacognosy
• 出 处: 高等学校化学研究：英文版
• 发表日期: 2012年2期
• 关键词: 衍生物 抗肿瘤活性 甘草次酸 合成 BGC-823 HEPG2细胞 HELA细胞 肿瘤细胞株 Glycyrrhetinic acid derivative An
• 基金项目: Supported by the Project-sponsored by Scientific Research Foundation for Returned Overseas Chinese Scholars Ministry of Education of China（No.20080890）, the Key Project of Chinese University Science R

Twenty-five derivatives of glycyrrhetinic acid(GA) modified on the A-ring,at C30 and C11 positions were synthesized.Their in vitro cytotoxicity against various cancer cell lines[henrietta lacks strain of cancer cells(HeLa),human hepatocellular liver carci