Antifungal variant bis(bibenzyl)s from the liverwort Asterella angusta

• 作 者: Jian-Bo Qu Ling-Mei Sun Hong-Xiang Lou
• 机 构: School of Pharmaceutical Sciences Shandong University,Center for Drug Evaluation, SFDA,
• 出 处: Chinese Chemical Letters
• 发表日期: 2013年09期
• 关键词: antifungal isolation guided spectroscopic fractionation skeleton diethyl moiety

Bioassay-guided fractionation of the diethyl ether extract of the liverwort Asterella angusta led to the isolation of two antifungal bis(bibenzyl)s,riccardin I(1),and angustatin A(2).Their structures were established by spectroscopic analysis(1D NMR and 2D NMR,IR,MS).Compound 1 is a novel variant riccardin-type bis(bibenzyl),while compound 2 is the first nonheteratom-containing variant bis(bibenzyl)possessing a bibenzyl-phenanthrene skeleton.

Bioassay-guided fractionation of the diethyl ether extract of the liverwort Asterella angusta led to the isolation of two antifungal bis (bibenzyl) s, riccardin I (1), and angustatin A (2) .Their structures were established by spectroscopic analysis and 2D NMR, IR, MS) Compound 1 is a novel variant riccardin-type bis (bibenzyl), while compound 2 is the first nonheteratom-containing variant bis (bibenzyl) possessing a bibenzyl-phenanthrene skeleton.