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卡比多巴(carbidopa)为强力的 L-芳香氨基酸脱羧酶抑制剂,与左旋多巴合并应用时,能抑制外周多巴脱羧酶的作用,从而减少多巴在脑外的耗损,维持脑内较高的多巴胺(DA)含量,同时能显著减轻左旋多巴的外周副作用,临床可作为左旋多巴的重要辅助药用于震颤麻痹症的治疗。我们用荧光分光光度法测定小鼠脑内多巴胺含量,证实了国产卡比多巴的药理作用。实验动物为雌性小鼠,体重17～23g,禁食18小时后,分为对照组和给药组,每组4只。分别给于1%甲基纤维素液(0.4ml/只)和卡比多巴
Carbidopa, a potent L-aromatic amino acid decarboxylase inhibitor, inhibits the action of peripheral dopaminergic decarboxylase when used in combination with levodopa to reduce dopaminergic depletion in the brain and maintain intracerebral High dopamine (DA) content, at the same time can significantly reduce the peripheral side effects of levodopa, clinically useful as an adjunct to levodopa paralysis treatment. We measured the content of dopamine in the brain of mice by fluorescence spectrophotometry and confirmed the pharmacological effects of domestic carbidopa. Experimental animals for female mice weighing 17 ~ 23g, fasting 18 hours later, divided into control group and the administration group, 4 in each group. To 1% methylcellulose solution (0.4ml / only) and carbidopa