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载脂蛋白E（ apoE）在体内具有重要生物学功能，其基因多态性会引起apoE结构与功能发生改变。目前国内外对于apoE基因多态性与缺血性脑卒中相关性的研究结论并不统一，仍需大样本多中心的病例对照研究进一步探索。此外，对于 apoE 基因多态性与缺血性脑卒中相关性的内部机制研究仍未完善，联合应用基因组学与蛋白质组学技术也许可为阐释 apoE 基因多态性与缺血性脑卒中关联的分子生物学机制提供支持。“,”Apolipoprotein E(apoE) plays a vital role in the body.Its gene polymorphism can lead to the changes of structure and function of apoE.At present,studies worldwide have not achieved same conclusion of the relationship between gene polymorphism of apoE and ischemic stroke.Therefore multi center case-control studies with large samples are required for further verification .Moreover, the underlying biological mecha-nisms of the relationship between ischemic stroke and gene polymorphism of apoE have not been fully clari-fied so far.To apply the combination of genomics and proteomics technology may be conducive to study such molecular mechanisms.