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目的分析药物不良反应(ADR)发生规律及特点,为临床合理用药及药物安全性评价提供依据。方法对收集到的478例ADR报告进行统计分析及评价。结果男性患者ADR发生比例较大;ADR多发生在50岁以上的老年患者;抗菌药物、心血管药物、中药制剂、血液及生物制剂发生ADR比率较大;临床表现以皮肤及附件损伤最为常见,其次为神经系统和胃肠道系统。结论应重视ADR监测,加强对医务人员ADR知识的培训和宣传,开展全方位的ADR监测工作,减少和避免ADR的发生。
Objective To analyze the regularity and characteristics of adverse drug reaction (ADR) and provide basis for clinical rational drug use and drug safety evaluation. Methods A total of 478 ADR cases were collected for statistical analysis and evaluation. Results The incidence of ADR in male patients was large. ADR occurred in elderly patients over 50 years old. The incidence of ADR in antimicrobial drugs, cardiovascular drugs, traditional Chinese medicine preparations, blood and biological agents was relatively high. The most common clinical manifestations were skin and accessory injuries, Followed by the nervous system and the gastrointestinal system. Conclusion ADR monitoring should be emphasized, training and publicity on ADR knowledge of medical staff should be strengthened, and all-around ADR monitoring should be carried out to reduce and avoid the occurrence of ADR.