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目的探讨急性心肌梗死(AMI)患者血清肾素-血管紧张素-醛固酮系统(RASS)的变化及其临床意义。方法用放射免疫法检测30例心肌梗死患者PRA、AngⅡ和ALD血清含量并与正常对照组35例比较。结果急性心肌梗死组PRA、AngⅡ和ALD明显高于对照组(P<0.05),差异有统计学意义。结论 RASS参与心肌梗死的发生和发展,测定PRA、AngⅡ和ALD可作为判断病情的一个指标,有助于心肌梗死的早期诊断和治疗。
Objective To investigate the changes of serum renin - angiotensin - aldosterone system (RASS) in patients with acute myocardial infarction (AMI) and its clinical significance. Methods Serum levels of PRA, AngⅡ and ALD were measured by radioimmunoassay in 30 patients with myocardial infarction and compared with 35 normal subjects. Results The levels of PRA, Ang Ⅱ and ALD in acute myocardial infarction group were significantly higher than those in control group (P <0.05). The difference was statistically significant. Conclusions RASS participates in the occurrence and development of myocardial infarction. The determination of PRA, AngⅡand ALD may be used as an index to judge the condition, which is helpful for the early diagnosis and treatment of myocardial infarction.