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目的：探讨炎症及冠状动脉狭窄在不稳定性心绞痛（ＵＡ）发生发展中的作用以及二者的相互关系。 方法：用酶联免疫双抗体夹心（ＥＬＩＳＡ）法测定２０例ＵＡ患者（ＵＡ组），２２例稳定性劳累型心绞痛（ＳＡ）患者（ＳＡ组），以及 ２５例正常人（正常对照组）的血浆可溶性白细胞介素－６受体（ｓＩＬ－６Ｒ）和血小板α颗粒膜蛋白－１４０（ＧＭＰ－１４０）水平。同时对ＵＡ及ＳＡ患者行冠状动脉造影，按积分法评定其冠状动脉狭窄程度，对结果进行统计学分析。 结果：①ＵＡ组患者血浆ＳＩＬ－６Ｒ及ＧＭＰ－１４０水平显著高于ＳＡ组（Ｐ＜０．０５）及正常对照组（Ｐ＜０．００１），而后两组间差异不显著（Ｐ＞０．０５）。②ＳＡ组患者冠状动脉狭窄程度较ＵＡ组严重，差异具有显著性（Ｐ＜０．０５）。③ＵＡ组患者ｓＩＬ－６Ｒ、ＧＭＰ－１４０水平与其冠状动脉狭窄程度间无相关性。 结论：结果显示ＵＡ患者体内存在着炎性反应，可能与其冠状动脉病变的不稳定有关；在判断预后方面，炎性细胞因．子水平的变化较之冠状动脉狭窄可能更为重要。
Objective: To investigate the role of inflammation and coronary artery stenosis in the development of unstable angina (UA) and their relationship. Methods: Twenty patients with UA (UA group), 22 patients with stable angina pectoris (SA) and 25 healthy controls (normal control group) were enrolled in the study. Plasma soluble interleukin-6 receptor (sIL-6R) and platelet-derived granule membrane protein-140 (GMP-140) levels. At the same time, UA and SA patients underwent coronary angiography, according to the integral method to assess the degree of coronary artery stenosis, the results were statistically analyzed. Results: ① The levels of plasma SIL-6R and GMP-140 in UA group were significantly higher than those in SA group (P <0.05) and normal control group (P <0.001), but there was no significant difference between the two groups (P> 0.05). 05). ② The degree of coronary artery stenosis in patients with SA was more serious than that in patients with UA, the difference was significant (P <0.05). There was no correlation between the levels of sIL-6R and GMP-140 in patients with UA and the degree of coronary artery stenosis. Conclusion: The results show that there is an inflammatory reaction in UA patients, which may be related to the instability of coronary artery lesions. In predicting the prognosis, inflammatory cytokines. Sub-level changes may be more important than coronary stenosis.